Hi there! I've been taking a GLP-1 shot for almost a year, and it seems like I'm not losing weight anymore. Does it stop working after your body gets used to it? Thank you! 😊
Hailey
My GLP-1 Stopped Working?
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haileylquinnFounding MemberAwarded to early adopters of the forum
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Hi Hailey. While it's possible to develop tolerance to any medication, I haven't really seen any strong evidence suggesting that the body develops tolerance to the weight-loss effects of GLP-1s over time. The weight loss does, however, tend to plateau after the initial phase of rapid weight reduction, which can give the impression that the medication is becoming less effective. This happens because as body weight decreases, the body’s energy requirements also drop, making further weight loss slower.
The good news is that studies show that most people who stay on the medication continue to maintain their weight loss or experience gradual improvements over time. Also, I cannot stress enough the importance of making lifestyle changes while on any weight loss medication. The reason is because, unfortunately, stopping semaglutide often leads to weight regain unless you also make lifestyle changes. This suggests that its effects are maintained with continued use, rather than being diminished due to tolerance.
What I've personally done, and which has helped tremendously, is to use the new positive physical and mental changes that I've experience while being on Ozempic to motivate me go to the gym at least 3 days a week. Now, two years later, I'm in my mid 50's and I've never felt better because I'm in the best shape that I have ever been in. It is possible at any age to feel your best with the right intention and effort.
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